This Information Can Save Your Life — Don’t Ignore It! Why HLA Typing and Cancer Prevention Matter
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Assalamu Alaikum friends, I hope you are all well.
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This Image is generated using AIReally This post is very important for someone
Avoid Grammer MistakesThis post of mine today is very important for you people to read. It may save someone's life. If you want to contribute to it, then the entire post is definitely worth reading. This post of mine today is very important for you people to read. It may save someone's life. If you want to contribute to this, then you must read the entire post. Cancer is a disease that scares people more than anything else. It is a very dangerous disease that people are very afraid of. Listen to me carefully. Many people know people who live with them, such as people who have never drunk alcohol, never smoked, and never smoked cigarettes, but still get cancer. And you must know many people who drink alcohol and smoke cigarettes but do not get cancer. It is not that drinking alcohol and smoking cigarettes does not cause cancer. It is clear that drinking alcohol causes more than seven types of cancer. Smoking causes about 16 types of cancer. Smoking causes about 16 types of cancer, but there are not only 16 types of cancer, there are more than 200 types of cancer that have been counted in research so far. It is even clear that drinking alcohol and smoking are very important for cancer. It is clear that drinking alcohol and smoking are major causes of cancer, but it is also important to note that there are many other things or factors that can cause cancer. Well, now the question is, what are the factors that cause cancer and by paying attention to them, we can eliminate our risk of cancer, and what kind of disease is this cancer that is very dangerous for human health? In today's post, I want to talk about cancer in detail and my goal is to tell you how we can help others, how we can save a human life. Saving a human life is a matter of great pride.
This will be the first post on my Hive account that I am writing outside of coding here, so check it out on my account first. All the posts will be about programming and coding.This will be the first post on my Hive account that I am writing here outside of programming. Before that, you should check out my account. All the posts that will be there will be related to programming and coding. I don't write other types of posts much and this is probably my first post. Okay, so now the question is why I consider it important to see this post. There may have been a post like this before, but I haven't seen it.
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Here I would also like to make this point from the community in which I am posting this, that community does not accept such posts, that is, that community is about photography, so why am I posting in this community? The answer to this is that it has the most subscribers in the community, that is, the most users have joined this community. I am posting in this community because maybe one person will act on this, maybe someone can save someone's life. If this is against the rules of this community, then I apologize. My intention is not to go against the rules of this community, but I felt that this community has the most subscribers and it is very appropriate to post in it.
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I might make some mistakes while writing in English because my native language is not English and I am not a complete professional in English. If there is any mistake, please ignore it.
Let me tell you something.
A small child, probably only a year or two old, whose name you can assume is Chirag. When Faraz's parents took him to the hospital for a routine checkup, they found that his hemoglobin level was very low. A test revealed that Chirag had a blood disorder called Thalassemia major. Because of this, the body is unable to properly produce hemoglobin and healthy red blood cells. Because of this, the body is unable to produce hemoglobin and healthy red blood cells properly, meaning Ahmed will need blood for the rest of his life. Every year, around 10,000 to 15,000 children in India are diagnosed with thalassemia. It’s no wonder that India is known as the thalassemia capital of the world. It’s a chronic disease, meaning your risk of cancer can increase. A 2015 study in Taiwan found that thalassemia patients have a 52 percent higher risk of cancer than the general population. Every three weeks, when Ahmed was taken to the hospital for a blood transfusion, he would ask his parents, “My friends don’t go to the hospital, why am I being taken?” Every day, billions of cells die and billions of new cells are formed in our body. Specifically, 330 billion cells, or about one percent of the total number of cells in our body, are replaced every day. There is a philosophical saying that the human being who we were this morning is like a river changing. This is literally true in the context of our body, and this gradual change, the daily regeneration of cells, is carried out by stem cells. The regeneration that takes place in different tissues is carried out by the stem cells of that tissue. But in all of this, one organ in our body is very unique, our liver. Our liver is a very unique organ because there are fully developed, fully specialized liver cells that can also divide and increase their number rapidly. That is, the liver is the only organ in our body that works like a lizard's tail. If you cut it off, it will grow back. Even if you cut off 90 percent of our liver and throw it away, our liver will grow back. But that doesn't mean the liver can't be damaged. If you say beer is not alcohol, alcohol is good for health, or if you are one of those people who says I can only swallow so many small pills at a time, then drinking alcohol has the worst effect on the liver and also greatly increases the risk of liver cancer, but not just alcohol. If you keep eating junk food, gaining weight, taking anything in the name of herbal medicines, you can still have liver problems. About two lakh people die every year in India due to liver diseases, which accounts for 18.3% of deaths from liver disease worldwide. But back to the topic of stem cells and regeneration. Now one thing needs to be clarified that the self-renewal and regeneration rates of different types of body cells in our body vary. As this major study from May 2008 shows, 10% of the body's fat cells are replaced every year. This means that it takes about 10 years to replace all the fat cells in the body. A very interesting topic here is whether our brain cells can also regenerate. This has been a subject of scientific debate for a long time. It is believed that most of the neurons in our brain are formed by the time we are born, about 100 billion neurons. However, recent research has indicated that limited neurogenesis, i.e. the regeneration of brain cells, has been observed in only two parts of the brain. One is the hippocampus, which is involved in our memories, learning and emotions. The other is the olfactory bulb, which is responsible for smelling. Other neurons in the brain do not regenerate and remain the same throughout life. In addition to the brain, very little regeneration has been observed in the spinal cord, heart, and joints. So if you get a disease or injury in these places, it is very harmful. However, in contrast, there are cells in the body that regenerate very quickly, which takes a very short time. For example, our skin cells shed 500 million skin cells every day. This means that our entire skin regenerates every four weeks, and even four weeks is not enough time to regenerate quickly. The lining of our intestines can completely regenerate in just five to seven days. Two to three million new red blood cells can be produced in one second. Their average lifespan is only 120 days. Stem cells also have the ability to replicate and renew themselves. There is the possibility of renewal. Just think about it. It is amazing how our body is constantly trying to renew us. It's constantly regenerating new cells. That's why if you fall and get injured, it's not a big deal because your skin cells regenerate. If you donate your blood, your blood volume, the volume of plasma, is restored within 24 hours. The same number of red blood cells that you gave to someone else, they come back in four to six weeks. It's all about replenishment, repair, and regeneration. But what happens if a gene is damaged in a cell? You can think of genes as a program that contains a detailed set of instructions for a cell. If there is a change or malfunction in the genes of a cell, it is called a mutation and this can disrupt the growth of the cell. Our body has some options available for such a situation. Some mechanisms within our body, such as repressor genes, are like a safety guard. This gene produces a protein that can repair the damaged gene. Similarly, there is a gene that acts like a filter. If a cell gets too old or damaged, the gene instructs it to die. This process is called programmed cell death or apoptosis. The cell is literally saying, brother, your job is done, disappear. From here, there are some other genes that act like mechanics that repair the damaged genes. So, let's look at it in a broader sense. If there is any damage happening to our cells, our body has security guard genes, filter genes and mechanic genes. During all this, our damaged cells can be prevented from growing, repairing themselves, or being removed from the body. But the question to consider is, what if these genes themselves become damaged? These security guard, filter, and mechanic genes become damaged. Then who will take over their job? Unfortunately, there is none, and such a situation is called cancer. Due to mutation, if the genes of a cell are damaged and they start growing and spreading uncontrollably, then such a cell is called a cancer cell. Cancer cells become so out of control that they even block the path of normal healthy cells. These cancer cells often have the ability to start from one part of the body, but gradually, if it is not stopped, it starts spreading to other parts of the body. When a cancer cell starts spreading from one part of the body to other parts of the body, this process is called metastasis. The normal functioning of our body is completely disrupted. Due to this, what exactly are the reasons behind such gene damage and how can they be avoided? We will talk about it at the end of the post. Now let's talk about treatment. The most famous treatment for cancer is chemotherapy. These cancer cells are destroyed by some power. This process with the help of powerful chemicals is called chemotherapy. The biggest problem with this process is that these powerful chemicals kill cancer cells, but at the same time they also destroy some good healthy cells. Chemotherapy chemicals target cells that are in the middle of the division process, so they are attacked along with the fast-growing healthy cells and cancer cells of the body. This is why people who are undergoing chemotherapy often go bald because our hair follicle cells are very fast-growing cells. At the same time, as I said, the cells inside our intestines also regrow very quickly. Therefore, digestive problems occur during chemotherapy. Vomiting, diarrhea, and other symptoms occur. In addition, our bone marrow cells are also destroyed. Bone marrow is the soft spongy tissue found inside our bones. One is the yellow bone marrow where there are stem cells that become fat cartilage or bone cells. The other is the red bone marrow where there are blood stem cells that become red blood cells, white blood cells or platelets. As I said, our blood cells are also very fast-growing cells, so they also get damaged due to chemotherapy. Anemia can occur due to lack of red blood cells. The hemoglobin level often drops. The platelets that are present help in blood clotting. When we get injured or a wound comes somewhere, they stop that wound. But if they are low, there will be excessive bleeding. The white blood cells in the wound help in our immunity. If we get a cold, we fight it off. But if the white blood cells are low due to chemotherapy, the chances of getting other diseases also increase. That's why doctors suggest chemo. During therapy, you should have a balanced nutritional diet, get enough sleep, stay away from stress, wash your hands regularly, wear a mask, avoid bacterial and viral infections with the help of food hygiene, and exercise regularly. When Bollywood actor Sanjay Dutt was undergoing cancer treatment, his college doctor, Sevin Thi Lamine, told that even on the day of chemotherapy, he used to exercise on the treadmill for an hour. Perhaps this is why he was able to recover so well. Now, let's say that the cancer cells were eliminated through chemotherapy.
How to restore healthy blood cells that have been destroyed, what can be done to recover them? But the question arises, how to restore healthy blood cells that have been destroyed? For this, a stem cell transplant is done, also known as a bone marrow transplant. It is a treatment option for patients with blood cancer and blood disorders. In some cases, the patient can be given some of the person's own healthy stem cells. In such cases, the patient's blood is taken from one side, the stem cells are separated in an apheresis machine, and the remaining blood is returned to the other side. The cancer cells are destroyed by chemotherapy and these stem cells are then returned. In many cases, another donor is needed because the patient's own bone marrow is not enough, and healthy blood cells cannot be found. In such cases, it is called an allogeneic stem cell transplant, just like in the case of a blood transfusion, your blood type must be matched with the donor's to receive the blood. To get a stem cell transplant, you must match your HLA type. Your HLA type is also its full form. Human Leukocyte Antigen Typing. Without going into further details, know that HLA is an important part of the immune system. There is a 25% chance that your HLA typing will be exactly the same as your brother or sister. It can never match your parents because one part comes from your parent and the other part comes from the other parent. So if there is no match with your brother or sister, you have to get a good type match from an unrelated person and the chances of it being a perfect match become very small. One in a million. Only one person in every hundred thousand people in the world will find someone with whom your HD type matches. How to find a matching donor? In such cases, here is the role. Friends, the Stem Cell Registry is a global non-profit organization of DKMS, whose tagline is: They create their own database worldwide to end blood cancer. From this database, they found a donor for the lamp. The lamp whose story I told you at the beginning of the post was the donor of Roman Siemens, who is from Natalia Rus but has been living in Germany since 2005. Roman is a precision mechanic but loves kickboxing. Once his kickboxing team donated blood. Roman has also been donating blood since school, so he did too. He was asked if he would like to give a swab sample. A swab sample is taken from the cheek by putting it inside the mouth. So he said yes, why not? About a year after doing so, DKMS contacted Roman and told him that his HLA typing matched someone and he could donate stem cells. Roman says it wasn't important to him that he was going to donate to someone, it was just that his donation would save someone's life. He said yes and donated his stem cells to Ahmed.
Stem cells, my friend, are also found in our peripheral blood, that is, the blood that runs through our heart, arteries, veins, and capillaries. Stem cell donation sounds like a big word, but it's actually a simple three- to four-hour procedure. To donate stem cells, you need to make it as simple as donating. There's just one difference. When your blood is taken from your arm, it's first sent to a machine where the stem cells are separated and then that same blood is returned to your body. Basically, only the stem cells are taken from your blood and the rest of the blood is returned to your body. This process is called PBSC, peripheral blood stem cell method. And as we know, stem cells can regenerate themselves, so after some time, the body can regenerate stem cells from the rest of the body. Let's take something like this: Roman saved Ahmed's life through stem cell donation. Ahmed was able to fully recover. After recovering, Ahmed wrote a letter to Roman that brought tears to the eyes of Roman and his wife. Chirag had called him his brother and his hero. Roman said in a flat voice that he has a younger brother of his own who is actually the same age as Chirag. In May tprevious year, the two met face-to-face for the first time. In some way, you can save someone's life. You can also become a giant for someone. If all the readser who read the post register, we can reduce blood cancer to a single link. I hope that none of you have blood cancer or a blood disorder and will never have it, but still you can find out your HLA typing and keep it known. So, it is a good thing to click on this link:
An online form will appear. In this form, you will have to fill in basic details such as your name, age, and address. A few days after registering, a completely free swab kit will be delivered to your home. In this swab kit, you will get three clean sterilized buckles, webs, buckle, swab, envelope, consent form, and an instruction sheet. You will have to follow the instructions given in this instruction sheet. Close this sample in the envelope provided in the same kit along with the signed consent form and request a reverse pickup of this envelope using the methods shown on the screen. Then, using your sample, your HLA type will be determined. The entire process will take about 40 days to complete. After that, you will receive an email from DKMS, which will say, "Congratulations, you have now been fully registered in the World Stem Cell Donor Database." If you want to know your HLA type, the donor must perform the following steps: You can email medical@dkms-bmst.org./ donor@dkms-bmst.org. After that, if your HLA type matches with a blood cancer patient, you will get a call for stem cell donation. This is very rare. It can take a week to a year to get a call. It may also happen that you never get a call in your entire life because no one needs your specific type. But if you get a call for donation, it is up to you whether you are comfortable for donation or not. This is a voluntary process. In this movement, you can decide whether you want to donate your stem cells or not. But the entire process is completely free. You do not need to bear any expenses. The expenses are bearby DKMS NGO. Now let's talk about the causes of gene damage. What is the last reason that some cells get damaged in this way? There are three main causes of cancer. The first is inherited mutation, meaning you are born with a mutated gene. This usually happens when you inherit this damaged gene from your parents. In some cases, it can also happen when you were an embryo and this mutated gene developed there. It is the cause of all cancers in the world, meaning that it is present in the body from childhood. The second cause is age. As you age, your genes start to wear out, which is why more cancer cases are seen in older people.
That is, the highest chance of getting cancer is between the ages of 80 and 90. This is because gene damage has been building up along with the aging process. Either you died at a young age due to dengue malaria, or you lived so long that you became a cancer patient. Cancer is more common in developing countries compared to developed countries because other diseases are less common in digitization. People live longer and if people live longer, the risk of gene damage increases. Unfortunately, the two causes I have told you about so far have become Hindus. Now you cannot change anything and your age will continue to increase. You cannot stop it. But we can do a lot about the third cause. This is lifestyle causes. Look at this 2017 analysis conducted by the American Cancer Society. The good news is that 42 percent of cancer cases are preventable. They are caused by lifestyle factors. About 19 percent of cancer cases that people get in the world are caused by smoking alone, 5.6 percent are caused by alcohol. So it is very clear that first of all Alcohol and smoking should not be consumed at all. Secondly, if you are overweight or obese, bring your weight into the right zone because this accounts for 7.8 percent of cancer cases. Third, UV radiation accounts for 4.7 percent of cases. UV radiation is the sun's harmful ultraviolet rays. Check your weather app in the afternoon to see what the UV index is. If the UV index is above 5, then ultraviolet rays can be very damaging to your skin. The same ultraviolet rays penetrate your skin and cause skin cancer. Getting tanned or sunburned due to repeated sun exposure is an indication of this, and it is a very dangerous thing. There are two ways to avoid it. First, do not go out in the sun from 10 am to 4 pm. This is the time when the Ayubi index is highest. Especially during summers, it is not so high in winters, so enjoy the sun in the morning or evening. Second, if you actually have to go out during this time, fourth, about five percent of cancer cases are due to physical inactivity and poor diet. Eliminate processed foods and added sugar from your diet and include as many different types of different colored vegetables, fruits, berries, nuts, seeds, herbs, whole grains, beans, milk, and all of these. Packaged food often contains chemicals that are carcinogenic, which increase the risk of cancer, but often these things are discovered only after a long time. So, the safe waste option is to avoid packaged food, eat natural food, eat fresh food and eat local. It is very important to have an active lifestyle. Keep exercising regularly, which should include stretching, cardio and strength training. Stretching is a great exercise in which we stretch the muscles. Cardio is where weightlifting is done. Then there is the angle of environmental exposure. Air pollution and many pesticides that are used, which cause cancer. Somewhere in your working environment, benzene, benzene, vinyl chloride, arsenic are not being used because according to the International Agency for Research on Cancer, all of them fall into the category of human carcinogens. Exposure to pesticides and fertilizers can cause cancer, and air pollution is not in your control, but you should reduce your exposure as much as possible. There is one major factor that is responsible for 20 to 25 percent of cancer cases, especially in developing countries, and that is why. Viruses. You heard right. Different types of viruses can also cause cancer. For example, hepatitis B virus, hepatitis C virus, HIV virus, human herpes virus, human T-lymphotropic virus, medical self-polyma virus, and HPV virus. There is a simple solution to avoid them. It is important to get the vaccines recommended by your doctor. Get vaccinated against hepatitis B. Get vaccinated against hepatitis C. Often, this vaccine is given to people in childhood. But HPV is a new vaccine. It is also important to get vaccinated to protect against the HPV virus. So keep all these things in mind. Friends, if you pay attention to these things, your and your family's risk of cancer will be greatly reduced. Another way to protect blood cancer patients is to get vaccinated against blood cancer. I asked you to register with DKMS today. By doing this, you can give hope to millions of blood cancer patients.
My Goal
My goal was to tell you about this website, to tell you about this organization so that you can register with it and save someone's life. I apologize if I made any grammatical mistakes. I hope I told you what I wanted to tell you.
Thank you very much for reading this entire post of mine. I request all of you to definitely register on it. Maybe someone's life will be saved because of you. I fold my hands in front of those who are not registering on it even after reading this post of mine. Maybe someone's life will be saved. Please definitely register.
I only know of this DKMS. There may be other organizations that are doing this kind of work. You should definitely register with them.
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